Cruyssen is a Dutch topographic surname, derived from the word kruis ("cross"), perhaps referring to a crossroads or a place marked by a cross. The name likely originated from a specific locale in the Netherlands, though the exact place remains uncertain. As a habitational name, Cruyssen identifies families who lived near a notable cross—such as a stone cross or a roadside crucifix—often used as a meeting point or a boundary marker in medieval times.
The variant Crusan and Krusen reflect common shifts in spelling and pronunciation across Dutch-speaking regions. The geographic distribution of the surname, while not extremely widespread, is emblematic of the Low Countries' toponymic naming tradition. While specific notable bearers are not widely recorded today, the name endures in far fewer numbers compared to its variants.